Vimentin is involved in regulation of mitochondrial motility and membrane potential by Rac1
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چکیده
منابع مشابه
Vimentin is involved in regulation of mitochondrial motility and membrane potential by Rac1
In this study we show that binding of mitochondria to vimentin intermediate filaments (VIF) is regulated by GTPase Rac1. The activation of Rac1 leads to a redoubling of mitochondrial motility in murine fibroblasts. Using double-mutants Rac1(G12V, F37L) and Rac1(G12V, Y40H) that are capable to activate different effectors of Rac1, we show that mitochondrial movements are regulated through PAK1 k...
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ژورنال
عنوان ژورنال: Biology Open
سال: 2015
ISSN: 2046-6390
DOI: 10.1242/bio.011874